PIGMENTATION TREATMENT IN Skin pigmentation affects the color of your skin. Your skin can get uneven pigmentation when the color-producing cells, called melanin, are damaged or affected. This can result in uneven patches on the face or throughout the body. Skin pigmentation can be the result of medical conditions or environmental factors such as sun exposure. Infections or burns and blisters can also cause pigmentation of the skin, which often leads to skin patches in the affected area. While it is not always harmful, it is not good for your skin to look uneven, and it can make it look unhealthy and feel unattractive.